Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

complex diseases using fast variance components analysis Po-Ru Loh1,2, Gaurav Bhatia1,2, Alexander Gusev1,2, Hilary K Finucane3, Brendan K Bulik-Sullivan2,4, Samuela J Pollack1,2,5, Schizophrenia Working Group of the Psychiatric Genomics Consortium†, Teresa R de Candia6, Sang Hong Lee7, Naomi R Wray7, Kenneth S Kendler8, Michael C O’Donovan9, Benjamin M Neale2,4, Nick Patterson2, Alkes L Price1,2,5 1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. 2 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. 3 Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. 5 Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. 6 Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, United States. 7 The Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. 8 Department of Psychiatry and Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA 9 MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK † A full list of members is provided in the Supplementary Note. Correspondence should be addressed to P.-R.L. ([email protected]) or A.L.P. ([email protected]).